Regulation of fatty acid beta-oxidation

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, ILDR1, and ADCY6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TJP3 grouped by Regulation of fatty acid beta-oxidation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TJP3 →	+2.526	+0.338	.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	ILDR1 →	+1.453	+0.377	.004	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ADCY6 →	+2.211	+0.411	.002	<.001	3	3
LIVER	FOSL1 →	-3.629	-0.267	.001	.004	3	3
BONE	THNSL1 →	-0.976	-0.300	.009	.009	2	4
KIDNEY	DAPK3 →	-0.639	-0.264	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TJP3 by Regulation of fatty acid beta-oxidation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →