Regulation of fatty acid beta-oxidation

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, RPA2, and PIGT, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid beta-oxidation activity versus CPT1A in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CPT1A →	+2.928	+1.815	<.001	<.001	3	13
BONE	RPA2 →	-1.197	-1.561	.005	.002	3	6
LUNG_SCLC	PIGT →	+0.843	+1.288	.002	.006	3	6
BLOOD_Leukemia	UBE2D1 →	-0.468	-1.472	.003	<.001	3	6
OESOPHAGUS	STRAP →	-0.509	-1.186	.004	.003	3	5
OESOPHAGUS	HSF2 →	-0.693	-1.320	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031998 vs CPT1A — OVARY

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