Regulation of glucocorticoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of glucocorticoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR5690, ABITRAM, and AFF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucocorticoid biosynthetic process activity versus MIR5690 in CCRCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MIR5690 →	+1.494	+0.756	<.001	<.001	3	4
UCEC	ABITRAM →	-0.399	-0.487	<.001	.005	3	3
LUAD	AFF2 →	+0.615	+0.612	<.001	.001	3	3
GBM	LGI3 →	+1.050	+0.419	.001	<.001	3	3
CCRCC	DRD5 →	+0.359	+0.547	.001	.002	3	3
GBM	DUSP14 →	-0.271	-0.488	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031946 vs MIR5690 — CCRCC

Explore this scatter interactively →