Regulation of glucocorticoid metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of glucocorticoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP88_S517, DNAJC7, and SRPK1_S311, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucocorticoid metabolic process activity versus NUP88_S517 in LUAD (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NUP88_S517 →	-0.428	-0.081	.001	<.001	3	7
LUAD	DNAJC7 →	-0.255	-0.066	<.001	.001	3	6
LSCC	SRPK1_S311 →	-0.542	-0.099	<.001	<.001	3	6
HNSC	FAM136A →	-0.318	-0.063	<.001	.002	3	5
COAD	NEK7 →	+0.284	+0.049	<.001	.001	3	5
CCRCC	SERBP1 →	-0.210	-0.069	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031943 vs NUP88_S517 — LUAD

Explore this scatter interactively →