Regulation of glucocorticoid metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of glucocorticoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1C2, DRD5, and NPEPPS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucocorticoid metabolic process activity versus ATP6V1C2 in LUAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATP6V1C2 →	-0.507	-0.421	.008	.003	3	4
GBM	DRD5 →	+0.207	+0.225	.001	.005	3	4
OV	NPEPPS →	-0.462	-0.853	<.001	<.001	3	3
GBM	CRHBP →	+0.545	+0.230	.003	.004	3	3
GBM	CAPN3 →	+0.434	+0.218	<.001	.006	3	3
BRCA	TNNI3K →	+0.041	+0.332	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031943 vs ATP6V1C2 — LUAD

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