Regulation of glucocorticoid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glucocorticoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUCLG2, CDK6, and FAM169A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUCLG2 grouped by Regulation of glucocorticoid metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SUCLG2 →	-0.864	-0.916	<.001	<.001	3	5
SOFT_TISSUE	CDK6 →	+2.970	+1.454	.008	<.001	3	4
SOFT_TISSUE	FAM169A →	-2.518	-1.475	.008	<.001	3	4
BLOOD_Leukemia	MLC1 →	-3.048	-1.125	.003	<.001	3	4
BLOOD_Leukemia	E2F1 →	+1.022	+1.028	<.001	<.001	3	4
BLOOD_Leukemia	AEBP1 →	+3.521	+1.074	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUCLG2 by Regulation of glucocorticoid metabolic process activity — PANCREAS

Explore this box plot interactively →