Regulation of glucocorticoid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glucocorticoid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR1, PPP2R5C, and MSLN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBR1 grouped by Regulation of glucocorticoid metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CBR1 →	-0.178	-0.143	.001	<.001	3	5
OVARY	PPP2R5C →	+0.280	+0.120	.004	.004	3	4
LIVER	MSLN →	+0.230	+0.221	.008	.001	3	4
PANCREAS	INPP5E →	-0.297	-0.160	.003	.005	3	4
BLOOD_Leukemia	PLCB4 →	+0.188	+0.126	.008	.004	3	4
BLOOD_Leukemia	ZNF76 →	+0.235	+0.093	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBR1 by Regulation of glucocorticoid metabolic process activity — SKIN

Explore this box plot interactively →