TOR signaling

Across TCGA patient cohorts, RNA activity of the TOR signaling pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, SEPTIN4_S432, and CACNA2D1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TOR signaling activity versus MAP1B in OV (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAP1B →	+0.493	+0.029	.005	.003	3	7
COAD	SEPTIN4_S432 →	+0.642	+0.022	<.001	.001	3	7
HNSC	CACNA2D1 →	+0.907	+0.062	<.001	<.001	3	7
COAD	MAP1A →	+0.345	+0.019	<.001	<.001	2	8
OV	LRP1 →	+0.485	+0.033	.006	.004	3	6
HNSC	CSNK1A1 →	-0.657	-0.077	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031929 vs MAP1B — OV

Explore this scatter interactively →