TOR signaling

Across TCGA patient cohorts, RNA activity of the TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR7E13P, RN7SL471P, and TMCC2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TOR signaling activity versus OR7E13P in OV (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OR7E13P →	+0.241	+0.116	.004	<.001	3	2
OV	RN7SL471P →	-0.293	-0.148	.006	.001	3	2
BRCA	TMCC2 →	-0.852	-0.113	.004	.006	3	2
OV	SNRPD3 →	+0.633	+0.121	.001	.007	3	1
OV	CRYBB3 →	+0.713	+0.129	.001	<.001	3	1
OV	MLC1 →	+0.800	+0.105	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031929 vs OR7E13P — OV

Explore this scatter interactively →