TOR signaling

Across TCGA cell cohorts, RNA activity of the TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP32, RASSF4, and ITGB6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TOR signaling activity versus ARHGAP32 in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARHGAP32 →	+2.045	+0.281	<.001	<.001	3	6
SOFT_TISSUE	RASSF4 →	-2.461	-0.266	<.001	.006	3	4
STOMACH	ITGB6 →	+1.978	+0.188	.001	.002	3	4
STOMACH	STARD9 →	-1.411	-0.210	.004	<.001	3	4
STOMACH	KALRN →	+3.207	+0.265	<.001	.001	3	4
STOMACH	FUT1 →	+1.961	+0.281	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031929 vs ARHGAP32 — STOMACH

Explore this scatter interactively →