Positive regulation of synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic plasticity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LOX, SRPX2, and PLOD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic plasticity activity versus LOX in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LOX →	+0.774	+0.051	<.001	<.001	3	8
BRCA	SRPX2 →	+0.737	+0.041	<.001	.002	3	7
LUAD	PLOD2 →	+0.931	+0.131	<.001	<.001	3	7
BRCA	HTRA1 →	+0.614	+0.034	<.001	.001	3	7
OV	PLOD1 →	+0.557	+0.080	.003	.005	3	7
UCEC	TUBB6 →	+0.427	+0.083	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031915 vs LOX — BRCA

Explore this scatter interactively →