Positive regulation of synaptic plasticity

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of synaptic plasticity pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Positive regulation of synaptic plasticity pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and ESCA, show the opposite pattern, with higher activity associated with better survival.

READ, KIRC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.778	0.975	.001	70	view →
KIRC	DFS	Quartile	II,III,IV	0.382	0.729	<.001	66	view →
LGG	DFS	Median	All	0.654	0.803	<.001	54	view →
KICH	DFS	Tertile	III,IV	0.309	1.000	.006	52	view →
KIRP	OS	Median	All	0.538	0.826	<.001	49	view →
BRCA	DFS	Median	All	0.413	0.581	<.001	45	view →
CESC	DFS	Quartile	II,III,IV	0.608	0.861	<.001	44	view →
STAD	OS	Quartile	All	0.486	0.810	.003	33	view →
HNSC	OS	Quartile	III,IV	0.547	0.837	<.001	33	view →
ACC	DFS	Quartile	All	0.329	0.774	<.001	30	view →
UVM	DFS	Quartile	All	1.000	0.555	.015	29	view →
BLCA	OS	Quartile	All	0.572	0.710	.010	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0031915–READ (OS)

Open the READ breakdown →