Positive regulation of synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1A, ARHGEF25, and MAP1B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic plasticity activity versus TUBA1A in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TUBA1A →	+4.386	+0.327	.001	.006	2	9
STOMACH	ARHGEF25 →	+3.644	+0.330	<.001	.001	3	8
LUNG_NSCLC_LUSC	MAP1B →	+3.470	+0.582	.002	.002	3	7
LUNG_SCLC	TMEM63A →	-2.332	-0.256	<.001	.001	3	7
LUNG_NSCLC_LUSC	FXYD3 →	-6.746	-0.654	<.001	.007	3	7
STOMACH	DBN1 →	+2.503	+0.376	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031915 vs TUBA1A — STOMACH

Explore this scatter interactively →