Positive regulation of lipopolysaccharide-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SASH1, SEPTIN14P12, and PLAGL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipopolysaccharide-mediated signaling pathway activity versus SASH1 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SASH1 →	+0.796	+0.435	<.001	<.001	3	7
GBM	SEPTIN14P12 →	-0.723	-0.239	<.001	<.001	3	5
LSCC	PLAGL1 →	+0.453	+0.491	.006	.001	2	5
LSCC	KLF9 →	+0.499	+0.403	.004	.004	3	4
GBM	FGF1 →	+0.670	+0.263	.001	.001	3	4
GBM	KIF14 →	-0.707	-0.233	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031666 vs SASH1 — GBM

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