Positive regulation of lipopolysaccharide-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCA, HTRA1, and AXL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipopolysaccharide-mediated signaling pathway activity versus PRKCA in BLOOD_Lymphoma (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRKCA →	-1.860	-0.114	<.001	<.001	3	7
BREAST	HTRA1 →	-2.954	-0.140	<.001	.002	3	6
SKIN	AXL →	-3.013	-0.093	.004	.002	3	6
BONE	LPP →	-2.462	-0.206	.007	.005	3	5
URINARY_TRACT	ZNFX1 →	-0.555	-0.111	.006	<.001	3	5
SKIN	S100A3 →	-2.701	-0.086	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031666 vs PRKCA — BLOOD_Lymphoma

Explore this scatter interactively →