Regulation of lipopolysaccharide-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A3, FBXL16, and SPATS2L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipopolysaccharide-mediated signaling pathway activity versus SLC16A3 in LUNG_SCLC (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC16A3 →	-2.026	-0.158	.002	.001	3	6
OESOPHAGUS	FBXL16 →	+1.303	+0.109	.002	.005	2	6
OESOPHAGUS	SPATS2L →	-1.250	-0.108	.003	.002	3	5
SKIN	HPS4 →	+1.253	+0.219	<.001	<.001	3	5
PANCREAS	BCL10 →	-0.841	-0.187	.002	.001	3	5
SKIN	DHRS3 →	-3.122	-0.268	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031664 vs SLC16A3 — LUNG_SCLC

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