Lipopolysaccharide-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMSN1, CD69, and BIN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipopolysaccharide-mediated signaling pathway activity versus SAMSN1 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMSN1 →	+0.685	+0.144	<.001	<.001	3	7
LSCC	CD69 →	+0.944	+0.225	<.001	<.001	3	6
GBM	BIN2 →	+0.586	+0.168	.001	.007	3	6
LSCC	ARHGDIB →	+0.601	+0.166	<.001	<.001	3	6
UCEC	SELL →	+0.988	+0.217	.002	.002	2	7
GBM	RBM15B →	-0.277	-0.178	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031663 vs SAMSN1 — LSCC

Explore this scatter interactively →