Lipopolysaccharide-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC74B, ARSK, and DEF8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC74B grouped by Lipopolysaccharide-mediated signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC74B →	+1.490	+1.329	<.001	<.001	3	4
OESOPHAGUS	ARSK →	+0.922	+1.347	.002	<.001	3	4
KIDNEY	DEF8 →	-0.683	-0.920	<.001	.005	3	4
URINARY_TRACT	SLC16A10 →	+1.336	+2.094	.002	<.001	3	4
STOMACH	H4C15 →	-1.563	-1.167	.001	<.001	3	4
CNS	SPOCD1 →	-2.545	-0.878	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC74B by Lipopolysaccharide-mediated signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →