Protein destabilization

Across TCGA patient cohorts, RNA activity of the Protein destabilization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSDMA, STAT5A_S128, and THOC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein destabilization activity versus GSDMA in HNSC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GSDMA →	-0.859	-0.063	.005	.008	3	4
COAD	STAT5A_S128 →	+0.292	+0.039	.009	.001	3	4
LUAD	THOC5 →	+0.163	+0.038	.007	<.001	3	4
OV	ADD3_S442 →	+0.748	+0.057	.007	.001	3	4
GBM	RASSF4 →	+0.464	+0.042	<.001	<.001	3	4
GBM	REL →	+0.264	+0.044	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031648 vs GSDMA — HNSC

Explore this scatter interactively →