Negative regulation of myelination

Across TCGA patient cohorts, RNA activity of the Negative regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR4308, DNAJC11, and WFS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myelination activity versus MIR4308 in LUAD (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4308 →	-0.652	-0.602	.005	.007	3	4
GBM	DNAJC11 →	-0.262	-0.115	.001	.008	3	4
PDAC	WFS1 →	-0.415	-0.557	.009	.003	3	3
LUAD	STRN →	-0.252	-0.495	.001	.009	3	3
LSCC	ATP6V1C1 →	-0.285	-0.608	.002	.002	3	3
LSCC	C1orf52 →	-0.216	-0.451	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031642 vs MIR4308 — LUAD

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