Regulation of myelination

Across TCGA patient cohorts, RNA activity of the Regulation of myelination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIP4K2A, YME1L1, and GNB4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myelination activity versus PIP4K2A in GBM (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIP4K2A →	+0.504	+0.068	<.001	<.001	3	8
CCRCC	YME1L1 →	-0.229	-0.042	<.001	<.001	3	7
BRCA	GNB4 →	+0.299	+0.038	<.001	<.001	3	7
CCRCC	MRPS35 →	-0.298	-0.044	<.001	<.001	3	7
GBM	APOE →	+0.598	+0.082	.002	<.001	3	7
LUAD	PTCD3 →	-0.202	-0.033	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031641 vs PIP4K2A — GBM

Explore this scatter interactively →