Regulation of myelination

Across TCGA cell cohorts, RNA activity of the Regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERRFI1, CCDC88B, and DNAH5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERRFI1 grouped by Regulation of myelination-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ERRFI1 →	-1.607	-0.322	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CCDC88B →	+2.288	+0.258	.005	.008	2	4
UPPER_AERODIGESTIVE_TRACT	DNAH5 →	+0.983	+0.229	<.001	.006	3	3
CNS	ZNF853 →	+1.358	+0.686	<.001	.003	3	3
KIDNEY	FGR →	+0.086	+0.602	<.001	.008	3	3
STOMACH	EIF2B2 →	-0.741	-0.363	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERRFI1 by Regulation of myelination activity — PANCREAS

Explore this box plot interactively →