Regulation of myelination

Across TCGA cell cohorts, RNA activity of the Regulation of myelination pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPTE2P3, CSNK1D, and SLA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPTE2P3 grouped by Regulation of myelination-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TPTE2P3 →	+0.190	+0.090	<.001	.008	3	5
OESOPHAGUS	CSNK1D →	+0.174	+0.076	<.001	<.001	3	4
BLOOD_Myeloma	SLA2 →	+0.267	+0.090	.002	.008	3	3
LUNG_NSCLC_LUSC	PNPLA5 →	-0.180	-0.122	.003	.001	3	3
LUNG_NSCLC_LUSC	MLLT1 →	+0.240	+0.077	.005	.003	3	3
LUNG_NSCLC_LUSC	NTN3 →	+0.168	+0.076	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPTE2P3 by Regulation of myelination activity — BLOOD_Myeloma

Explore this box plot interactively →