Regulation of myelination

Across TCGA cell cohorts, RNA activity of the Regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, CRB3, and TMEM184A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myelination activity versus TJP3 in OVARY (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TJP3 →	-2.268	-1.138	<.001	.002	3	5
OVARY	CRB3 →	-2.868	-1.182	<.001	<.001	3	5
OVARY	TMEM184A →	-1.694	-1.082	.001	<.001	3	5
OVARY	C1orf210 →	-2.179	-0.982	.006	.004	3	5
BLOOD_Leukemia	MDM2 →	-1.015	-0.637	.003	.003	3	4
LARGE_INTESTINE	RBBP8NL →	-1.363	-0.866	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031641 vs TJP3 — OVARY

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