Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, CASKIN1_S1257, and CROCC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane activity versus ZYX in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZYX →	-0.471	-0.380	<.001	.003	3	5
GBM	CASKIN1_S1257 →	+1.078	+0.422	<.001	<.001	3	5
BRCA	CROCC →	+0.345	+0.227	<.001	.002	3	5
BRCA	GSTM3 →	+1.511	+0.289	<.001	<.001	3	5
GBM	HOOK1 →	+0.915	+0.389	<.001	<.001	3	5
GBM	CRTAP →	-0.562	-0.366	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031632 vs ZYX — GBM

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