Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APLP1, TMEM8B, and PRSS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane activity versus APLP1 in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	APLP1 →	+0.716	+0.693	.001	.002	3	4
LSCC	TMEM8B →	+1.120	+0.246	<.001	.003	3	3
GBM	PRSS3 →	+0.540	+0.786	<.001	<.001	3	3
GBM	KIF1A →	+0.779	+0.987	<.001	<.001	3	3
GBM	GPD1 →	+1.036	+0.621	.007	.004	3	3
GBM	ERBB4 →	+0.933	+0.668	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031632 vs APLP1 — GBM

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