Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT9, CCR7, and MORC3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYT9 grouped by Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SYT9 →	-0.633	-2.179	.003	.001	2	11
CNS	CCR7 →	-0.534	-1.237	.001	.005	2	8
CNS	MORC3 →	-0.502	-1.400	<.001	<.001	3	7
STOMACH	SYT1 →	-0.281	-1.610	.007	<.001	3	7
BLOOD_Leukemia	GTPBP3 →	-0.318	-1.094	<.001	<.001	3	7
BLOOD_Leukemia	TEF →	-0.364	-1.180	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYT9 by Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane activity — BLOOD_Myeloma

Explore this box plot interactively →