Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JDP2, PLEKHO1, and PPFIA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JDP2 grouped by Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	JDP2 →	+1.575	+1.076	.001	.005	3	4
BLOOD_Myeloma	PLEKHO1 →	-4.570	-2.033	<.001	<.001	3	4
BREAST	PPFIA4 →	-1.154	-1.070	.002	.002	3	4
UPPER_AERODIGESTIVE_TRACT	MAP1A →	-0.275	-1.564	.004	.002	3	4
BLOOD_Leukemia	C16orf72 →	-0.867	-1.249	<.001	<.001	3	3
OESOPHAGUS	PTPRU →	+1.264	+1.226	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JDP2 by Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane activity — OESOPHAGUS

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