Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3D, PPP6R1, and SLC9A3R1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane activity versus EIF3D in LUNG_SCLC (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EIF3D →	-0.925	-2.098	.008	.004	3	1
LUNG_SCLC	PPP6R1 →	+0.850	+2.412	.001	<.001	3	1
LUNG_SCLC	SLC9A3R1 →	-1.698	-2.185	.003	.006	3	1
LUNG_SCLC	GPRC5D →	+1.917	+1.981	.003	.008	3	1
LUNG_SCLC	TIMELESS →	+0.643	+1.586	.004	.001	3	1
LUNG_SCLC	CHPT1 →	-1.920	-1.983	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031632 vs EIF3D — LUNG_SCLC

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