Positive regulation of fever generation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fever generation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF485, AGXT, and ZNF442, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF485 grouped by Positive regulation of fever generation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF485 →	+0.350	+1.728	.008	.001	3	4
OVARY	AGXT →	-0.149	-1.038	.001	.003	3	4
BONE	ZNF442 →	+0.161	+1.701	.001	.007	3	4
LUNG_NSCLC_LUSC	ATCAY →	-0.237	-1.046	<.001	.006	3	3
BREAST	UQCRC2 →	-0.349	-0.992	.009	<.001	3	3
BREAST	IL17RD →	-0.191	-0.925	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF485 by Positive regulation of fever generation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →