Regulation of termination of DNA-templated transcription

Across TCGA patient cohorts, RNA activity of the Regulation of termination of DNA-templated transcription pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHFPL6, CLEC11A, and TMEM204, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of termination of DNA-templated transcription activity versus LHFPL6 in CCRCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LHFPL6 →	-0.909	-0.873	<.001	.002	3	4
BRCA	CLEC11A →	-0.859	-0.318	.001	.001	3	3
BRCA	TMEM204 →	-0.737	-0.366	<.001	.003	3	3
CCRCC	PTGIR →	-0.707	-1.024	<.001	<.001	3	3
BRCA	SLC16A9 →	-0.510	-0.338	.004	<.001	3	3
BRCA	TPSAB1 →	-1.502	-0.421	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031554 vs LHFPL6 — CCRCC

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