Brain-derived neurotrophic factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Brain-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETMAR, TNS1_S1588, and TGFB1I1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brain-derived neurotrophic factor receptor signaling pathway activity versus SETMAR in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SETMAR →	+0.299	+0.080	<.001	<.001	3	5
HNSC	TNS1_S1588 →	+0.613	+0.077	.003	.008	3	5
GBM	TGFB1I1 →	+0.388	+0.087	.003	<.001	3	5
GBM	ADAP1 →	-0.610	-0.088	.004	.001	3	5
GBM	COL5A1 →	+0.631	+0.076	.001	<.001	3	5
LSCC	EFHD2 →	-0.342	-0.099	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031547 vs SETMAR — BRCA

Explore this scatter interactively →