Brain-derived neurotrophic factor receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Brain-derived neurotrophic factor receptor signaling pathway pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Brain-derived neurotrophic factor receptor signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and KICH, show the opposite pattern, with higher activity associated with better survival.

MESO, LAML, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.324	0.735	<.001	104	view →
LAML	DFS	Quartile	All	0.422	0.675	.006	30	view →
READ	OS	Quartile	III,IV	0.573	0.951	.002	28	view →
THYM	OS	Median	All	0.738	0.960	.005	21	view →
KIRP	DFS	Median	IV	0.035	0.458	.018	18	view →
ESCA	OS	Median	II,III,IV	0.581	0.410	.017	15	view →
LUAD	DFS	Median	All	0.563	0.717	.007	10	view →
KICH	DFS	Tertile	III,IV	1.000	0.269	.027	9	view →
SARC	DFS	Tertile	All	0.719	0.543	.003	9	view →
SCLC	DFS	Tertile	II,III,IV	0.873	0.206	.006	9	view →
KIRC	DFS	Tertile	All	0.711	0.521	.031	8	view →
PRAD	OS	Median	All	0.899	0.856	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0031547–MESO (OS)

Open the MESO breakdown →