Brain-derived neurotrophic factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Brain-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC4, AEBP1, and CNN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brain-derived neurotrophic factor receptor signaling pathway activity versus NFATC4 in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFATC4 →	+0.787	+0.152	.002	.003	2	5
UCEC	AEBP1 →	+1.080	+0.199	<.001	<.001	3	4
UCEC	CNN1 →	+2.524	+0.198	<.001	<.001	3	4
UCEC	COLEC12 →	+0.968	+0.195	<.001	<.001	3	4
UCEC	LMOD1 →	+1.796	+0.210	<.001	<.001	3	4
UCEC	MSRB3 →	+1.341	+0.182	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031547 vs NFATC4 — UCEC

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