Subtelomeric heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Subtelomeric heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNDP2, SEC22C, and GSTO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Subtelomeric heterochromatin formation activity versus CNDP2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CNDP2 →	-1.369	-0.450	<.001	.002	3	5
SOFT_TISSUE	SEC22C →	-0.882	-0.400	.008	.002	3	4
SKIN	GSTO1 →	-0.974	-0.344	<.001	<.001	3	4
LARGE_INTESTINE	YIF1B →	-0.662	-0.259	.006	.004	3	4
LARGE_INTESTINE	COASY →	-0.419	-0.238	.001	.003	3	4
OESOPHAGUS	ENC1 →	-1.145	-0.316	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031509 vs CNDP2 — UPPER_AERODIGESTIVE_TRACT

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