Protein-containing complex localization

Across TCGA cell cohorts, RNA activity of the Protein-containing complex localization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBF4, ORC1, and SRRT, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex localization activity versus DBF4 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DBF4 →	+0.884	+0.075	.006	.002	3	11
KIDNEY	ORC1 →	+1.304	+0.092	<.001	.004	2	12
BLOOD_Lymphoma	SRRT →	+0.884	+0.059	<.001	<.001	3	10
KIDNEY	NDC1 →	+1.181	+0.122	<.001	<.001	3	10
SKIN	DNMT1 →	+0.855	+0.064	<.001	<.001	3	10
BREAST	MKI67 →	+1.070	+0.062	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031503 vs DBF4 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →