Positive regulation of mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTG3, GPATCH11, and ZCCHC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTG3 grouped by Positive regulation of mRNA 3'-end processing-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BTG3 →	-1.366	-0.181	.006	<.001	3	4
BONE	GPATCH11 →	-0.488	-0.108	.005	.008	3	4
SOFT_TISSUE	ZCCHC2 →	+0.968	+0.138	<.001	.001	3	4
BLOOD_Lymphoma	CPSF3 →	-0.727	-0.164	<.001	.003	3	3
LUNG_NSCLC_LUSC	CNIH3 →	+1.335	+0.081	.005	.004	3	3
BLOOD_Lymphoma	OSBPL11 →	-1.175	-0.148	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTG3 by Positive regulation of mRNA 3'-end processing activity — BLOOD_Lymphoma

Explore this box plot interactively →