Regulation of mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF891, CPEB2, and MGLL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA 3'-end processing activity versus ZNF891 in SKIN (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF891 →	+0.525	+1.144	<.001	<.001	3	5
CNS	CPEB2 →	-0.936	-0.750	.002	.003	3	5
BREAST	MGLL →	-1.835	-0.874	<.001	<.001	3	5
BREAST	ABCC3 →	-2.449	-0.992	.001	<.001	3	4
OVARY	NR3C1 →	-1.111	-0.780	.007	.008	2	5
OESOPHAGUS	APBA2 →	+2.387	+0.885	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031440 vs ZNF891 — SKIN

Explore this scatter interactively →