Positive regulation of protein ubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC3_S71, PTPN2_S304, and AHNAK_S5318, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein ubiquitination activity versus TACC3_S71 in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TACC3_S71 →	+0.822	+0.032	<.001	<.001	3	6
BRCA	PTPN2_S304 →	+0.505	+0.019	.004	.007	3	6
PDAC	AHNAK_S5318 →	-0.517	-0.023	.002	.003	3	6
LUAD	RRM2 →	+0.515	+0.030	<.001	<.001	3	5
LUAD	SETDB1_S1066 →	+0.616	+0.034	<.001	<.001	3	5
LUAD	SMARCA4_S1452 →	+0.296	+0.029	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031398 vs TACC3_S71 — LUAD

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