Positive regulation of cell killing

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell killing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTK2B, PTPN6, and CYRIB, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell killing activity versus PTK2B in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTK2B →	+0.296	+0.043	<.001	<.001	3	10
GBM	PTPN6 →	+0.567	+0.053	<.001	<.001	3	10
OV	CYRIB →	+0.426	+0.037	.001	<.001	3	10
HNSC	SPN →	+0.595	+0.059	<.001	<.001	3	9
UCEC	THEMIS2 →	+0.486	+0.049	.005	.001	3	9
GBM	TNFAIP8 →	+0.743	+0.064	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031343 vs PTK2B — LSCC

Explore this scatter interactively →