Positive regulation of cell killing

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell killing pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX9, SRSF8, and LRCH4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX9 grouped by Positive regulation of cell killing-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DHX9 →	-0.547	-0.125	<.001	<.001	3	5
BREAST	SRSF8 →	-0.101	-0.102	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	LRCH4 →	+0.151	+0.137	<.001	.004	3	4
STOMACH	ZCCHC7 →	-0.106	-0.113	.004	.006	3	4
LARGE_INTESTINE	RAC2 →	+0.230	+0.118	.002	<.001	3	4
LARGE_INTESTINE	SLC24A5 →	-0.203	-0.139	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX9 by Positive regulation of cell killing activity — LARGE_INTESTINE

Explore this box plot interactively →