Negative regulation of cell killing

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell killing pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF726, HOMER1, and PLEKHA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF726 grouped by Negative regulation of cell killing-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF726 →	-0.772	-0.685	.001	<.001	3	5
BLOOD_Leukemia	HOMER1 →	+1.299	+1.355	.003	<.001	3	4
BLOOD_Myeloma	PLEKHA3 →	-0.834	-1.361	.002	.003	3	3
BREAST	FRMD4A →	-1.715	-0.952	<.001	.002	3	3
BREAST	PSMG4 →	-0.717	-0.824	.001	.002	3	3
SKIN	BTG1 →	+0.631	+0.639	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF726 by Negative regulation of cell killing activity — SKIN

Explore this box plot interactively →