Regulation of vesicle fusion

Across TCGA patient cohorts, RNA activity of the Regulation of vesicle fusion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTMAP3, MANCR, and MFNG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vesicle fusion activity versus PTMAP3 in COAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTMAP3 →	+0.443	+0.788	.002	<.001	3	3
COAD	MANCR →	+0.600	+0.790	.001	.001	3	3
LUAD	MFNG →	+0.284	+0.609	.002	<.001	3	3
BRCA	TBC1D4 →	+0.652	+0.556	.004	.002	2	4
LUAD	RNU6-1127P →	+0.639	+0.511	.002	.007	3	3
UCEC	PNO1 →	-0.456	-0.536	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031338 vs PTMAP3 — COAD

Explore this scatter interactively →