Negative regulation of protein-containing complex assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein-containing complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCUN1D4, TBC1D4, and DMAC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCUN1D4 grouped by Negative regulation of protein-containing complex assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DCUN1D4 →	-0.710	-0.206	.005	.004	3	4
OVARY	TBC1D4 →	-1.440	-0.194	.001	<.001	3	4
OVARY	DMAC1 →	-0.633	-0.145	.001	.001	3	4
OVARY	ADAP2 →	+1.679	+0.193	.001	.007	3	4
LUNG_SCLC	CALCOCO1 →	+0.765	+0.152	.001	.009	3	4
PANCREAS	RINL →	+1.628	+0.177	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCUN1D4 by Negative regulation of protein-containing complex assembly activity — STOMACH

Explore this box plot interactively →