Membrane protein intracellular domain proteolysis

Across TCGA cell cohorts, RNA activity of the Membrane protein intracellular domain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM9, DNAJC14, and RAB43, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein intracellular domain proteolysis activity versus ADAM9 in OESOPHAGUS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ADAM9 →	+1.390	+0.562	<.001	.002	3	7
LUNG_NSCLC_LUSC	DNAJC14 →	-1.002	-0.342	.001	.003	3	5
LUNG_NSCLC_LUAD	RAB43 →	+1.509	+0.322	<.001	<.001	3	5
CNS	KIRREL1 →	+1.216	+0.225	.001	.003	3	4
BONE	STK38 →	+1.626	+1.908	<.001	<.001	3	4
KIDNEY	MAZ →	-1.232	-0.440	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031293 vs ADAM9 — OESOPHAGUS

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