Retinal ganglion cell axon guidance

Across TCGA patient cohorts, RNA activity of the Retinal ganglion cell axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT88, IRF4, and IKZF1_S445, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal ganglion cell axon guidance activity versus IFT88 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFT88 →	+0.425	+0.125	<.001	<.001	3	6
LSCC	IRF4 →	-0.830	-0.082	<.001	<.001	3	6
BRCA	IKZF1_S445 →	-1.175	-0.053	<.001	.002	3	6
LSCC	MZB1 →	-0.626	-0.063	<.001	<.001	3	6
UCEC	DENND1C →	-0.505	-0.094	<.001	<.001	3	5
OV	CARMIL2_S1381 →	-1.797	-0.069	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031290 vs IFT88 — UCEC

Explore this scatter interactively →