Retinal ganglion cell axon guidance

Across TCGA cell cohorts, RNA activity of the Retinal ganglion cell axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-ND1, FUOM, and ITCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MT-ND1 grouped by Retinal ganglion cell axon guidance-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MT-ND1 →	+1.137	+1.363	.008	.005	2	4
PANCREAS	FUOM →	-1.613	-0.646	.002	.002	3	3
LIVER	ITCH →	-0.472	-0.909	<.001	.006	3	3
BLOOD_Myeloma	RPIA →	+0.633	+1.548	.006	.003	2	4
OVARY	PNO1 →	+0.513	+0.812	.002	.005	2	4
BREAST	CIT →	+0.842	+0.684	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MT-ND1 by Retinal ganglion cell axon guidance activity — KIDNEY

Explore this box plot interactively →