Retinal ganglion cell axon guidance

Across TCGA cell cohorts, RNA activity of the Retinal ganglion cell axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFA, ALCAM, and NRP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal ganglion cell axon guidance activity versus VEGFA in STOMACH (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VEGFA →	+1.910	+0.286	<.001	<.001	2	14
SOFT_TISSUE	ALCAM →	+3.296	+0.378	<.001	<.001	3	12
LIVER	NRP1 →	+2.806	+0.309	.002	<.001	3	12
BONE	ITGB1 →	+1.612	+0.383	<.001	<.001	3	10
LIVER	ADAM9 →	+1.690	+0.283	.004	.004	2	10
BLOOD_Lymphoma	E2F2 →	-1.088	-0.118	.003	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031290 vs VEGFA — STOMACH

Explore this scatter interactively →