Positive regulation of pseudopodium assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of pseudopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42EP4, CDC42EP1, and PRKCA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pseudopodium assembly activity versus CDC42EP4 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDC42EP4 →	+0.568	+0.287	<.001	.005	3	6
BRCA	CDC42EP1 →	+1.196	+0.844	<.001	<.001	3	5
BRCA	PRKCA →	+0.959	+0.902	<.001	<.001	3	5
UCEC	LRCH2 →	+0.736	+0.319	<.001	.001	3	4
UCEC	KIRREL1 →	+0.795	+0.397	<.001	.002	3	4
UCEC	PRKG1 →	+1.082	+0.468	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031274 vs CDC42EP4 — OV

Explore this scatter interactively →