Positive regulation of pseudopodium assembly

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of pseudopodium assembly pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Positive regulation of pseudopodium assembly pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and HNSC, show the opposite pattern, with higher activity associated with better survival.

CESC, HNSC, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.920	0.823	.003	80	view →
HNSC	OS	Quartile	All	0.502	0.337	.003	80	view →
ESCA	DFS	Median	III,IV	0.588	0.296	<.001	58	view →
MESO	OS	Tertile	All	0.245	0.493	<.001	48	view →
UVM	DFS	Tertile	II,III,IV	0.380	0.760	.005	28	view →
DLBC	OS	Median	II,III,IV	0.257	1.000	<.001	26	view →
READ	DFS	Quartile	IV	0.243	0.645	.014	16	view →
CHOL	DFS	Tertile	All	0.671	0.172	.002	15	view →
SCLC	DFS	Median	All	0.990	0.538	.004	14	view →
SKCM	DFS	Median	IV	0.561	0.142	.011	11	view →
LIHC	OS	Quartile	II,III,IV	0.776	0.275	.012	11	view →
OV	DFS	Median	IV	0.361	0.530	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0031274–CESC (OS)

Open the CESC breakdown →